The Digigram VXpocket 440 provides 24-bit performance with PC applications using Microsoft's WAVE protocol and ASIO, Mac applications using Core Audio and ASIO, as well as Linux applications using the ALSA standard.

The card feature one stereo SPDIF input and output allowing digital record/playback and an LTC (SMPTE) time-code input. A breakout cable is provided with XLR connectors for the analog inputs/outputs, phono connectors for digital and LTC, and a stereo mini-jack for headphone monitoring.

The Digigram VXpocket 440 has four balanced mic/line analog inputs and four balanced analog outputs. The number of active stereo inputs and outputs available varies with the sampling frequency and bit rate selected. The user may optimize performance based on user preferences for number of input/output, audio file format, and computer CPU usage.